[HTML][HTML] Systems pharmacology modeling identifies a novel treatment strategy for bortezomib-induced neuropathic pain
P Bloomingdale, C Meregalli, K Pollard… - Frontiers in …, 2022 - frontiersin.org
… and prevented bortezomib-induced mechanical allodynia and … Anti-TNFα antibodies have
shown to prevent allodynia in … that were significantly decreased in a rat model of BIPN (Figure 5…
shown to prevent allodynia in … that were significantly decreased in a rat model of BIPN (Figure 5…
[HTML][HTML] The actions and mechanisms of P2X7R and p38 MAPK activation in mediating bortezomib-induced neuropathic pain
Y Guo, X Xu, J Huang, Z Wang, Z Li, Z Liu - BioMed research …, 2020 - hindawi.com
… decrease through the expression of tumor necrosis factor-α (TNF… In the present study, a BIPN
rat model was established and used … with allodynia rat model was successfully established. …
rat model was established and used … with allodynia rat model was successfully established. …
[HTML][HTML] Inhibition of microRNA-155 reduces neuropathic pain during chemotherapeutic bortezomib via engagement of neuroinflammation
Z Duan, J Zhang, J Li, X Pang, H Wang - Frontiers in Oncology, 2020 - frontiersin.org
… of pro−inflammatory tumor necrosis factor-α receptor (TNFR1) in … Using this rat model, a recent
study showed that blocking … mechanical allodynia and thermal hyperalgesia in BTZ rats. In …
study showed that blocking … mechanical allodynia and thermal hyperalgesia in BTZ rats. In …
[HTML][HTML] High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats
C Meregalli, I Marjanovic, C Scali, L Monza… - Journal of …, 2018 - Springer
… able to significantly reduce bortezomib-induced heat and mechanical allodynia. Although …
Antibody against tumor necrosis factor-α reduces bortezomib-induced allodynia in a rat model…
Antibody against tumor necrosis factor-α reduces bortezomib-induced allodynia in a rat model…
Peripheral neuropathy following bortezomib therapy in multiple myeloma patients: association with cumulative dose, heparanase, and TNF-α
W Zhao, W Wang, X Li, Y Liu, H Gao, Y Jiang… - Annals of …, 2019 - Springer
… been related to bortezomib-induced peripheral neuropathy (… also established animal models
to observe the effect of anti-… bortezomib therapy reduced allodynia than rats treated with …
to observe the effect of anti-… bortezomib therapy reduced allodynia than rats treated with …
The association of neuronal stress with activating transcription factor 3 in dorsal root ganglion of in vivo and in vitro models of bortezomib-induced neuropathy
Y Yin, X Qi, Y Qiao, H Liu, Z Yan, H Li… - Current Cancer Drug …, 2019 - ingentaconnect.com
… technology resulted in decreased intracellular oxidative stress… induced painful peripheral
neuropathic rat model. We found … Furthermore, tumor necrosis factor-α (TNFα)-mediated c-Jun …
neuropathic rat model. We found … Furthermore, tumor necrosis factor-α (TNFα)-mediated c-Jun …
… Application of Magnesium-l-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-α/Nuclear Factor-κB …
T Xu, D Li, X Zhou, HD Ouyang, LJ Zhou, H Zhou… - …, 2017 - pubs.asahq.org
… necrosis factor-α/nuclear factor-κB signaling, and reduced free … Reducing Mg 2+ activated
tumor necrosis factor-α/nuclear … and incubated with the primary antibody against TNF-α (1:500; …
tumor necrosis factor-α/nuclear … and incubated with the primary antibody against TNF-α (1:500; …
[HTML][HTML] Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1
… in this non-tumor-bearing animal model, including an early … reduced the development of
mechanical allodynia evoked by … TNF-α or SDF-1 neutralizing antibody at 1 h after intrathecal …
mechanical allodynia evoked by … TNF-α or SDF-1 neutralizing antibody at 1 h after intrathecal …
[HTML][HTML] Bortezomib-induced peripheral neuropathy: clinical features, molecular basis, and therapeutic approach
Y Yang, B Zhao, H Lan, J Sun, G Wei - Critical Reviews in Oncology …, 2024 - Elsevier
… Although next-generation PIs result in a lower incidence rate … 3; TNF-α,tumor necrosis
factor-α; TRPA1, transient receptor … and/or allodynia) is a common feature in BIPN models, the …
factor-α; TRPA1, transient receptor … and/or allodynia) is a common feature in BIPN models, the …
Melatonin attenuates pain hypersensitivity and decreases astrocyte-mediated spinal neuroinflammation in a rat model of oxaliplatin-induced pain
Y Wang, Y Li, W Cui, L Li, Z Zhang, B Tian, G Zhang - Inflammation, 2017 - Springer
… shown to have anti-inflammatory and anti-allodynia effects in … -1β (IL-1β) and tumor necrosis
factor-α (TNF-α) and chemokines … peroxidase-conjugated secondary antibodies. The bands …
factor-α (TNF-α) and chemokines … peroxidase-conjugated secondary antibodies. The bands …